The overall objective of the BIOTHEREP Circular project is to create a novel and economically viable integrated processes that will convert slaughterhouse activities into environmentally friendly and sustainable practices, and reduce the risk of soil, climate, and water pollution. This will be done by implementing a fully circular processing of waste streams, into energy and other valuable by-products. The primary ambition of the BIOTHEREP project is to propose effective, optimized, and smart multidisciplinary technological solutions to the nowadays problems of slaughterhouse waste management affecting seriously climate-soil-water resources. In this project, last advanced and innovative materials together with technologies of emerging interests such as anaerobic digestion, biohydrogen production, pyrolysis, gasification, methanation process assessment will be considered to accomplish the zero-pollution ambition while mitigating greenhouse emission, and freshwater scarcity at low cost, producing bioenergy and extracting some added-value components, increasing sustainability, recycling and reuse of water sources.